The Science of Food Is Medicine

The evidence base, in one place.

The case for Food Is Medicine is decades deep — randomized trials, cost models, and policy reviews from the country's leading institutions. We pulled the work that matters into one growing, citable library, so clinicians, payers, and members can find the science without digging.

Medically Tailored Meals

Outcomes & utilization for the highest-need patients.

Association Between Receipt of a Medically Tailored Meal Program and Health Care Use

Medically tailored meal recipients had roughly half the inpatient admissions and fewer skilled-nursing admissions than matched non-recipients, with lower overall medical spending.

Berkowitz et al. · JAMA Internal Medicine · 2019
Medically Tailored Meal Delivery for Diabetes Patients with Food Insecurity: A Randomized Cross-Over Trial

In food-insecure adults with type 2 diabetes, 12 weeks of meals nearly doubled diet quality (HEI 71 vs. 40), cut food insecurity, and reduced self-reported hypoglycemia.

Berkowitz et al. · J. General Internal Medicine · 2019
Medically Tailored Meals and Healthcare Utilization and Costs in Massachusetts’ Medicaid Demonstration

Across 11 health systems and 3,238 Medicaid members, MTM receipt was associated with 31% fewer hospitalizations, 20% fewer ED visits, and $3,433 lower healthcare costs — offsetting 98% of program cost.

Nature Medicine · 2026
Effect of Medically Tailored Meals on Clinical Outcomes in Discharged Adults (KP NOURISH)

A pragmatic RCT of 1,977 patients. Ten weeks of post-discharge meals did not reduce all-cause hospitalization, but exploratory analyses showed lower mortality and fewer heart-failure hospitalizations.

Go et al. · Medical Care · 2022
Impact of Medically Tailored Meals & Nutrition Therapy on Food-Insecure Patients with Congestive Heart Failure

A matched-cohort study after CHF hospitalization. Participants trended toward better blood-pressure categories and healthier intake, though the small pilot did not reach statistical significance.

BMC Nutrition · 2022
Impact of Medically Tailored Meals on Clinical Outcomes Among Low-Income Adults with Type 2 Diabetes: A Pilot RCT

A Medicaid-population pilot pairing meals with nutrition therapy cut food insecurity from 53% to 17% and established feasibility for at-risk diabetes patients.

J. General Internal Medicine · 2025
Produce Prescriptions & FIM Trials

What randomized trials of food prescriptions show.

A Systematic Review of “Food Is Medicine” Randomized Controlled Trials for Noncommunicable Disease in the U.S.

Reviewed 14 U.S. RCTs. Food Is Medicine programs consistently improved diet quality and food security — the theorized drivers of better outcomes — while effects on clinical biomarkers were inconsistent, underscoring the need for larger, longer trials.

AHA Scientific Statement · Circulation · 2025
Effect of an Intensive Food-as-Medicine Program on Health and Health Care Use: A Randomized Clinical Trial

A rigorous RCT of an intensive grocery-plus-clinical program increased engagement with preventive care, but did not improve glycemic control vs. usual care — a key reminder that program design matters.

Doyle et al. · JAMA Internal Medicine · 2024
Produce Prescription Subsidy for Patients With Diabetes: A Pragmatic Randomized Clinical Trial

In 2,155 patients, an $80/month produce subsidy alone did not improve A1c or utilization at 12 months — evidence that food access works best paired with clinical support, not in isolation.

Duke / Reinvestment Partners · JAMA Internal Medicine · 2026
Impacts of a Produce Prescription Program on Food Security, Diet Quality & Psychosocial Health (12-Month Longitudinal)

Among Medicaid adults with chronic conditions, weekly home-delivered produce plus dietitian coaching improved diet quality and loneliness vs. SNAP-only, and cut food insecurity 17% over a year.

J. General Internal Medicine · 2026
Fresh Food Farmacy: A Randomized Controlled Trial

A landmark 500-patient RCT of Geisinger’s household-scale, dietitian-prescribed fresh-food program for food-insecure diabetics — one of the most cited operational models in the field.

Geisinger · ClinicalTrials.gov · 2019–2023
Reviews, Policy & The Field

How institutions are moving on Food Is Medicine.

Food Is Medicine: A Presidential Advisory From the American Heart Association

The AHA’s first presidential advisory on Food Is Medicine — a call to integrate food interventions into clinical care and build a definitive national research base.

Circulation · 2023
“Food Is Medicine” Strategies for Nutrition Security and Cardiometabolic Health Equity

A comprehensive clinical review of the FIM spectrum — meals, groceries, produce prescriptions — with evidence on diet quality, glucose, hypertension, and cost-effectiveness, plus guidance for clinicians and payers.

Mozaffarian et al. · JACC State-of-the-Art Review · 2024
Advances in Food-As-Medicine Interventions and Their Impact on Food Production & Supply Chains

Maps the Food Is Medicine intervention pyramid — from population diet guidance to medically tailored meals — and what scaling it means for the food system.

Advances in Nutrition · 2025
Food Is Medicine Research Action Plan

A field-defining roadmap that catalogs the peer-reviewed evidence base and sets 18 recommendations for how future FIM research should be designed, funded, and evaluated.

Aspen Institute Food & Society · 2024
Mainstreaming Produce Prescriptions in Medicaid Managed Care: A Policy Toolkit

A practical policy toolkit from Harvard’s Center for Health Law & Policy Innovation on how states and managed-care plans can fund and scale produce prescriptions through Medicaid.

Harvard Law CHLPI · 2023
Healthy Eating Rx: Improving Nutrition Through Health Care

A bipartisan working group, co-chaired by former cabinet secretaries, makes 10 recommendations to scale evidence-based FIM interventions and strengthen clinical nutrition education.

Bipartisan Policy Center · 2023
How Medically Tailored Meals Can Improve Healthcare Outcomes and Lower Cost

A foundational white paper synthesizing the early MTM evidence base — including Project Angel Heart, Project Open Hand, and MANNA — that helped open Medicaid and Medicare Advantage coverage pathways.

Community Servings / RWJF · 2019
Food Is Medicine: A Project to Unify and Advance Collective Action

The federal Food Is Medicine initiative, launched after the 2022 White House Conference on Hunger, Nutrition, and Health, to scale access nationwide.

U.S. Dept. of Health & Human Services (ODPHP)

This is a curated, growing library — not the entire field. We include null and mixed-result trials alongside positive ones, because honest evidence is the point. Findings are summarized from each study’s published abstract; follow the link for full methods, limitations, and context. We add new peer-reviewed work as it’s published.

Go Deeper

The institutions building the field.

We stand on their work. For the full bodies of research, start with the organizations defining Food Is Medicine — led by the team at Tufts.

Tufts Food is Medicine Institute

The leading academic home of Food Is Medicine, based at Tufts’ Friedman School. Runs the largest FIM clinical trials, cost-effectiveness modeling, and policy analysis in the field — the definitive starting point for the science.

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American Heart Association — Health Care by Food™

The AHA’s national initiative funding the next generation of FIM clinical trials and building the evidence base payers need to reimburse food-based interventions.

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The Rockefeller Foundation — Food is Medicine

Has committed more than $100 million since 2019 to advance FIM research, infrastructure, and policy in partnership with HHS, the VA, and the American Heart Association.

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Food Is Medicine Coalition (FIMC)

The national coalition of nonprofit medically tailored meal providers, with a continually updated library of published and in-process research and the field’s MTM standards.

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Aspen Institute — Food & Society

Author of the Food Is Medicine Research Action Plan, the roadmap cataloging the evidence base and setting research priorities for the field.

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Harvard Law CHLPI

The Center for Health Law & Policy Innovation produces the policy toolkits that help states and Medicaid plans fund and scale produce prescriptions and medically tailored meals.

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Kaiser Permanente — Food Is Medicine Center of Excellence

An integrated-health-system center bringing FIM screening, produce prescriptions, and medically tailored meals to members at scale while measuring outcomes and costs.

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Community Servings

Boston-based nonprofit and the largest medically tailored meal provider in the Massachusetts Medicaid demonstration, and a long-standing research partner behind the foundational MTM evidence.

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Bipartisan Policy Center

Convened a bipartisan Food Is Medicine working group whose recommendations are shaping federal coverage and nutrition-education policy.

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Health & Nutrition Coalition (Florida)

State-level research and advocacy advancing Food Is Medicine within Medicaid and managed-care programs.

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U.S. HHS — Office of Disease Prevention & Health Promotion

The federal Food Is Medicine initiative coordinating government-wide action following the 2022 White House Conference on Hunger, Nutrition, and Health.

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From the evidence to your kitchen.

The research is clear. See what it looks like in practice — our own member outcomes, or a two-minute check on your coverage.